Department of Life Sciences
The Department of Life Sciences of the E. Amaldi Foundation is active in the design, development and characterization of tools that have a real potential in terms of technology transfer in the field of life sciences, obviously without neglecting innovative research as a fundamental engine to ensure the advancement of scientific skills. In this respect, it promotes participation in research projects by responding to regional, national and international calls for proposals, aggregating both academic and industrial partners and coordinating the related consortium.
The Department of Life Sciences has also established a Working Group at the Italian Space Agency of spin in themes about space, in cooperation with the Technology Transfer Unit of the same Agency.
We are currently engaged in the manufacture and characterization of bioresorbable structures (scaffold) for tissue engineering and regenerative medicine and in the definition of innovative sensors for clinical diagnostics.
Tissue engineering represents a field of frontier research, since scaffolds realized according to the criteria of this interdisciplinary approach, allow the regeneration of new functional tissue, following a trauma or pathology, reproducing the microenvironment temporarily and as faithfully as possible natural. In this way we introduce the possibility of guiding the formation of the biological matrix to favor a complete physiological recovery. For this purpose, in the Department of Life Sciences, various methods are used, such as electrospinning and 3D printing, to ensure that the final structure meets specific requirements to be evaluated within the collaboration network, established and coordinated by the Department itself as an integral part of its activities.
Referring to the field of sensors, the synergistic combination of nanomaterials and biotechnologies has enabled the development of highly selective and highly sensitive detection devices for oncology applications. Being able to measure extremely low concentrations of pathological markers means having a tool that can provide a valuable contribution in terms of early diagnosis. A similar result can be achieved by functionalizing the measurement substrate appropriately, and analyzing it by means of Raman spectroscopy in SERS ( Surface Enhanced Raman Spectroscopy ) mode, which allows to amplify signals referring to the analyte of interest by several orders of magnitude. Still in the field of SERS approach sensors, the Department has activated several collaborations aimed at the realization of specific measurement devices for applications in the pharmacological and agri-food fields.
The activities in progress and those planned as forthcoming guidelines are made possible thanks to the integration of different professional profiles that draw on the fields of biomedical engineering, materials science and chemistry.
Tissue engineering is a frontier research field, since scaffolds allow for the regeneration of functional tissues, following a trauma or pathology, reproducing temporarily and as faithfully as possible the natural microenvironment. To this purpose, at the Bioengineering Department different methods are used, such as electrospinning and 3D printing, to ensure that the final structure meets specific requirements to be evaluated within the collaborative network established and coordinated by the Department as an integral part of its activities.
For what concerns the sensor industry, the synergic combination of nanomaterials and biotechnologies allows for the development of highly selective and highly sensitive detection devices for oncology applications. Being able to measure extremely limited concentrations of pathological markers means having a very valuable tool in terms of very early diagnosis. A similar result can be achieved by suitably functionalising the measurement substrate and analyzing it using SERS (surface enhanced Raman spectroscopy), allowing signals of interest to be amplified by several orders of magnitude. In the field of sensors for the SERS technology, the Department has activated several collaborations aimed to the development of measuring devices for applications in the pharmacological and in the agri-food field.
The ongoing activities and those already planned are made possible thanks to the integration of different professional profiles from the fields of biomedical engineering, materials science and chemistry.